CrossTalkeR Example - Human Myocardial Infarction

Vanessa Klöker

Institute for Computational Genomics, Faculty of Medicine, RWTH Aachen University, Aachen, 52074 Germany

James S. Nagai

Institute for Computational Genomics, Faculty of Medicine, RWTH Aachen University, Aachen, 52074 Germany

Ivan G. Costa

Institute for Computational Genomics, Faculty of Medicine, RWTH Aachen University, Aachen, 52074 Germany

Cell-Cell Communication Analysis of Human Myelofibrosis scRNA-seq Data Using CrossTalkeR

Here, we demonstrate the usage of CrossTalkeR on the case study of human myocardian infarction snRNA-seq data from the Nature paper “Spatial multi-omic map of human myocardial infarction” (Kuppe et al.). Aim of the study was to build a high-resolution map of human cardiac remodelling after myocardial infarction to provide a better understanding of these remodelling processes. We are focusing here on the conditions “myogenic” (control condition) and “ischaemic” (disease condition) and go through the CrossTalkeR results step by step.